Version 2.0 Beta · Updated September 24, 2025

Multi-Omics and Microbiome Associations in Cancer

Explore high-confidence host–microbe relationships across TCGA cohorts. MOMAC2 stratifies associations by confidence level using permutation-based validation to ensure reproducible discoveries.

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4 Omics Layers
24 Cancer Types
23063 Significant Links

What's New in 2.0

  • Confidence-stratified associations based on permutation testing
  • Rigorous benchmarking across 24 cancer types
  • Multi-omics integration with methylation, gene, and protein data
  • Experimental validation support for hypothesis generation
BETA VERSION

About MOMAC

MOMAC2 (Multi-Omics and Microbiome Associations in Cancer v2) is a stratified database for host–microbe interactions across TCGA cohorts. We provide confidence levels for associations between tumor microbiome profiles and multi-omics readouts.

Methodology at a Glance

We systematically compare TCGA-derived microbial profiles across cancer types. Associations undergo permutation-based benchmarking to assess statistical robustness and stratify by confidence level, ensuring reproducible and clinically meaningful signals.

Multi-dimensional Validation

Permutation-based benchmarking assesses statistical robustness and identifies reproducible associations.

Experimental Support

Findings validated through co-culture experiments and external datasets to guide hypothesis testing.

Why Researchers Choose MOMAC

  • Confidence-stratified associations across 24 cancer types
  • Rigorous statistical validation through permutation benchmarking
  • Framework for generating testable biological hypotheses
Dataset
Search by cancer type, microbe, feature, or use advanced filters.
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Search across TCGA cancer types, microbial species, genes, and cell markers.
API Reference
Keep features that remain significant after permutations.

Search Results

Page through results, explore detailed statistics, and export for downstream analysis.

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Dataset Overview

Generate a high-level view of the most enriched features per dataset.

Only features with adjusted p-value < 0.05 and permutation p-value < 0.05 are shown.

Select a dataset and feature type, then click “Generate” to visualize the 50 most enriched terms.

Download Datasets

Get TSV exports aligned with the MOMAC schema for downstream analyses.

Hosted by COmics Lab @ SUSTech

Poore et al. dataset

Ge et al. dataset

Additional files

Use the column manifest to map TSV fields to the portal views.

Archived MOMAC v1 Data

Legacy datasets from the original MOMAC publication with 509 downloadable files across multiple analysis methods.

Archive · v1.0
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